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Receptor targets: PT-141 primarily targets MC3R and MC4R with reduced MC1R activity

"Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: A randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial." The Lancet , 402(10404), 529-544

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Discussion Our cryo-EM and functional analyses indicate that the concurrent binding of one HGF to two c-METs by utilizing two completely distinct interfaces leads to c-MET dimerization and activation